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Boyko N. Nick, Zaytsev І. Alexander, Osolodchenko P. Тatyana, Melnik L. Аnatoly, Nevmerzhitskiy V. Vitaliy, Volkov О. Тaras and Kazmirchuk V. Victor



This paper presents data on the study of antimicrobial activity of 16 medications used for wound treatment. Antimicrobial activity of medications has been studied by well diffusion method on standard microorganism test strains: S. aureus ATCC 25923, E. coli ATCC 25922, P. aeruginosa ATCC 27853, P. vulgaris ATCC 4636, B. subtilis ATCC 6633, and C. albicans ATCC 885/653. Integrated indexes of antimicrobial activity of medications using vector theory have been calculated, which allowed to place most active of them in the order of descending activity: Levomecolum А = 2.73, r² = 0.82; Levosin А = 2.41, r² = 0.83; Synthomycinum А = 2.33, r² = 0.97; Methyluracilum cum myramistino А = 2.31, r² = 0.83; Oflocainum-Darnitsa А = 2.25, r² = 0.97; and Betadine А = 2.03, r² = 0.97. The mean of integrated indexes of antimicrobial activity and the square of the correlation coefficient for the group of these medications are as follows: A = 2.02, and r² = 0.91. Comparison of mean values of integrated indexes of antimicrobial activity of medicines for wound treatment with those of water-alcohol extracts from plant raw material containing alkaloids, tannins, hydroquinone, naphthoquinones, anthraquinones, and phenols has shown to be promising of further development of domestic agents having antimicrobial activity based on water-alcohol extracts from plant raw material.


Antimicrobial activity, wound medications, well diffusion method.

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